Demystifying extrachromosomal DNA circles: Categories, biogenesis, and cancer therapeutics
Since the advent of sequencing technologies in the 1990s, researchers have focused on the association between aberrations in chromosomal DNA and disease.However, not all forms of the DNA are linear archstone pets and chromosomal.Extrachromosomal circular DNAs (eccDNAs) are double-stranded, closed-circled DNA constructs free from the chromosome that